Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy
Eric R. Wengert, Sophie R Liebergall, Teresa Jimenez…·Ethan M. Goldberg
This study creates a mouse model with the KCNC1-A421V variant to investigate its effects on neuronal excitability and epilepsy, finding impaired function in fast-spiking interneurons and network dysfunction.