Transcriptomic splicing analysis reveals a gene-independent form of TE reactivation in tumors representing unrecognized source of oncogenes and neoantigens
Ziteng Li, Yichao Bao, Qin Li, Hongwu Yu, Hena Zhang, Yifan Wen, Yu Yang, Jingjing Zhao, Peng Lin, Yan Li, Zhixiang Hu, Xichun Hu, Xiaodong Zhu, Shenglin Huang
This paper identifies TEtrans, gene-independent transcripts from transposable elements in tumors, which act as oncogenes and neoantigens, expanding the role of TEs in cancer.
bioRxiv · Mar 1, 2025 · PreprintCancer Biology