De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response
Rui Yang, Kaiyuan Zheng, McGuire Metts, Yiluo Wang, Danyan YIN, Kevin P. Li, Agnieszka A. Prazmowska, David F. Kashatus, Brian A. Kuhlman, Jie Yang
This paper designs de novo proteins that bind DELE1, block its oligomerization, and inhibit the mitochondrial stress response in cells.
bioRxiv · May 18, 2026 · PreprintBiochemistry