Jie Yang

This paper designs de novo proteins that bind DELE1, block its oligomerization, and inhibit the mitochondrial stress response in cells.

This study presents cryo-EM structures of human ClpXP, revealing mechanisms of assembly and proteolytic activation through conformational changes and interactions.

ISDia tracks protein synthesis and clearance during ER stress, revealing PERK-dependent and independent regulatory mechanisms across subcellular compartments.

This study reports the cryo-EM structure of DELE1's C-terminal fragment, showing its oligomerization and role in activating the integrated stress response.

The paper determines the cryo-EM structure of yeast Lon protease (PIM1) and shows it forms a hexamer similar to bacterial and human Lon proteases, with unique structural features and a dispensable yeast-specific insertion.