David F. Kashatus

This study identifies DRP1 reactivation as a mechanism of resistance to MEK inhibition in pancreatic cancer cells and shows that inhibiting DRP1 can restore sensitivity to trametinib.

This paper designs de novo proteins that bind DELE1, block its oligomerization, and inhibit the mitochondrial stress response in cells.

The paper estimates protein copy numbers from mRNA data across 369 cell lines and applies it to reclassify breast cancer subtypes and predict viral receptor abundances.

The paper shows that the miR-206 family is not essential for myogenesis in vitro but affects mitochondrial function and muscle performance in vivo.