Author

McGuire Metts

University of North Carolina at Chapel HillORCID 0009-0002-3847-8061Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Brian A. KuhlmaniD· 2 shared Agnieszka A. Prazmowska· 1 shared Albert A. BowersiD· 1 shared Amrita NallathambiiD· 1 shared Avery K. HuberiD· 1 shared Danyan YIN· 1 shared David F. KashatusiD· 1 shared Henry DieckhausiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Brian A. KuhlmanORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 18, 2026

De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response

Rui Yang, Kaiyuan Zheng, McGuire Metts…·Jie Yang

This paper designs de novo proteins that bind DELE1, block its oligomerization, and inhibit the mitochondrial stress response in cells.

DOI 10.64898/2025.12.22.695711

humanprotein structure

𝕏 PostBluesky

BioengineeringbioRxivPreprintFeb 14, 2026

Enhancing ML-based binder design with high-throughput screening: a comparison of mRNA and yeast display technologies

Zhiyuan Yao, McGuire Metts, Avery K. Huber…·Brian A. Kuhlman

This study compares mRNA and yeast display technologies for evaluating ML-designed miniprotein binders, finding mRNA display better enriches slow dissociating binders and achieves higher library coverage.

1 citation

protein structureexperimental assay

𝕏 PostBluesky