Gangliosides GM3 And GD3 Modulate Insulin Aggregation Pathways and Reduce Cytotoxicity Through Structural Remodeling
Nazifa Ahmad, Jhinuk Saha, Yimin Mao, Robert Silvers, Zaid Abulaban, Joshua A. Mysona, Ayyalusamy Ramamoorthy
This study shows gangliosides GM3 and GD3 accelerate insulin aggregation into non-fibrillar structures that are less toxic than fibrillar aggregates, suggesting potential therapeutic implications for Type-2 Diabetes.
International Journal of Biological Macromolecules · Aug 28, 2026Peer-reviewedBiophysics