Jhinuk Saha

Gangliosides GM3 And GD3 Modulate Insulin Aggregation Pathways and Reduce Cytotoxicity Through Structural Remodeling

This study shows gangliosides GM3 and GD3 accelerate insulin aggregation into non-fibrillar structures that are less toxic than fibrillar aggregates, suggesting potential therapeutic implications for Type-2 Diabetes.

FAIM Inhibits Insulin Amyloidogenesis through a Noncanonical Aggregation Pathway

This paper identifies FAIM as an endogenous inhibitor of insulin amyloid formation by redirecting insulin toward non-toxic assemblies and reducing {beta}-sheet formation.

MAS cryoprobe enhances solid-state NMR signals of α-synuclein fibrils

This study demonstrates that a MAS cryoprobe significantly improves signal-to-noise ratio in solid-state NMR experiments on α-synuclein fibrils, enabling faster and higher-resolution spectroscopy.

SEC Purified Monomeric Aβ42 Produces Reproducible and Reliable Ag-gregation Measurements

This study compares SEC and chemical denaturation methods for preparing monomeric Aβ42, finding SEC produces more reliable aggregation measurements.

Higher Magnetic Field NMR Renders Resolution Enhancement on Ganglioside GD3 Catalyzed Abeta42 Aggregates

This study shows that high-field SSNMR improves resolution and sensitivity for analyzing heterogeneous Aβ42 aggregates catalyzed by GD3.

A Simple Algorithm to Suppress Diagonal Peaks in High-Resolution Homonuclear Chemical Shift Correlation NMR Spectra

The paper introduces a spectral shearing method to suppress diagonal peaks in NMR spectra while preserving cross peak sensitivity.

Anionic lipid catalyzes the generation of cytotoxic insulin oligomers

This study shows that anionic lipids like DMPG influence insulin aggregation pathways and intermediate formation, with soluble intermediates being more cytotoxic than fibrils.