Ayyalusamy Ramamoorthy

This study investigates how saponin chemistry affects bicelle properties like anionic lipid tolerance and divalent metal ion stability, identifying design principles for better membrane-mimetic systems.

This study shows that different polymorphs of lysozyme influence the structure and toxicity of cross-seeded insulin fibrils.

This study uses 31P and 14N solid-state NMR to analyze how cholesterol affects nanodisc formation and magnetic alignment in DMPC + glycyrrhizic acid systems, revealing optimal cholesterol concentrations for aligned bicelles.

This study shows gangliosides GM3 and GD3 accelerate insulin aggregation into non-fibrillar structures that are less toxic than fibrillar aggregates, suggesting potential therapeutic implications for Type-2 Diabetes.

This study uses molecular dynamics to uncover the assembly and stability mechanisms of peptide nanodiscs formed by 4F and identifies factors affecting their structure and function.

This paper identifies FAIM as an endogenous inhibitor of insulin amyloid formation by redirecting insulin toward non-toxic assemblies and reducing {beta}-sheet formation.

This study shows that structurally distinct amyloid polymorphs of HEWL have enhanced antibacterial activity compared to native HEWL, with flexible fibrils showing the strongest activity against multiple bacterial strains.

This study demonstrates that a MAS cryoprobe significantly improves signal-to-noise ratio in solid-state NMR experiments on α-synuclein fibrils, enabling faster and higher-resolution spectroscopy.

This study compares SEC and chemical denaturation methods for preparing monomeric Aβ42, finding SEC produces more reliable aggregation measurements.

The paper presents a dynamic NMR lineshape simulation framework for lipid diffusion and membrane thinning in bicelles and nanodiscs, enabling accurate interpretation of anisotropic NMR spectra.

This study shows that high-field SSNMR improves resolution and sensitivity for analyzing heterogeneous Aβ42 aggregates catalyzed by GD3.

This paper introduces a 2D NMR technique for homonuclear chemical shift correlation in solids under MAS, showing rapid spin-exchange between nearby 15N or 13C nuclei.

The paper introduces a spectral shearing method to suppress diagonal peaks in NMR spectra while preserving cross peak sensitivity.

This study shows that anionic lipids like DMPG influence insulin aggregation pathways and intermediate formation, with soluble intermediates being more cytotoxic than fibrils.

This study investigates how different gangliosides affect hIAPP aggregation and structure, finding that lipid-peptide ratios and charge/headgroup size influence aggregation and conformation.

This study reconstitutes and characterizes the C99 domain of APP in nanodiscs using multiple biophysical methods.