Resilience to dominant genetic disease in the healthy elderly
Paul A Lacaze, Robert Sebra, Moeen Riaz, Jane M. Tiller, Jerico Revote, James Phung, Emily J Parker, Suzanne Gaye Orchard, Jessica E. Lockery, Rory S Wolfe, Maya Strahl, Ying C. Wang, Rong Chen, Daniel Sisco, Todd Arnold, , Eric Schadt
The paper screens healthy elderly individuals to identify those resilient to genetic diseases despite high genetic risk, finding 141 individuals without associated disease despite pathogenic variants.
medRxiv · Oct 22, 2019 · PreprintGenetic & Genomic Medicine