Rory S Wolfe

Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population

This study examines the effect of APOE genotypes and polygenic risk scores on dementia and cognitive decline in a longitudinal cohort of healthy older individuals, finding increased risks for APOE ε4 carriers and high PRS tertiles.

Resilience to dominant genetic disease in the healthy elderly

The paper screens healthy elderly individuals to identify those resilient to genetic diseases despite high genetic risk, finding 141 individuals without associated disease despite pathogenic variants.

The Medical Genome Reference Bank: Whole genomes and phenotype of 2,570 healthy elderly

The paper introduces the Medical Genome Reference Bank, a resource of whole genome sequences and phenotypes from 2,570 healthy elderly Australians, showing fewer disease-associated variants and age-related somatic changes linked to grip strength.