Moeen Riaz

This study conducts GWAS on blood pressure traits in 140,559 admixed Mexican adults, identifying novel genetic signals and highlighting ancestry-specific heterogeneity.

This study performs a meta-analysis of GWAS to identify new genetic loci associated with all-cause and vascular dementia, revealing shared and distinct risk factors.

This study evaluates a polygenic risk score for coronary heart disease in individuals aged 70 and older, finding it improves prediction when added to conventional risk factors.

A polygenic risk score predicts mosaic loss of chromosome Y in men's blood cells, with higher scores linked to increased risk.

This study evaluates a polygenic risk score for breast cancer in women aged 70 and older, finding it improves risk prediction beyond conventional factors.

The paper identifies lipid-lowering genetic variants in older adults without CHD, showing their association with lower LDL-C and reduced statin use.

This study examines the effect of APOE genotypes and polygenic risk scores on dementia and cognitive decline in a longitudinal cohort of healthy older individuals, finding increased risks for APOE ε4 carriers and high PRS tertiles.

The paper screens healthy elderly individuals to identify those resilient to genetic diseases despite high genetic risk, finding 141 individuals without associated disease despite pathogenic variants.

The paper introduces the Medical Genome Reference Bank, a resource of whole genome sequences and phenotypes from 2,570 healthy elderly Australians, showing fewer disease-associated variants and age-related somatic changes linked to grip strength.