Cis-delivering releasable IL-15 superagonist enhances antitumor immunity in cold tumors by invigorating preexisting CD25+CD8+ T cells
Qiongya Zeng, Wencheng Kong, Ying Qin, Luyao Song, Nan Liu, Zexin Liu, Chenghao Ji, Gen Qi, Wenqiang Shi, Huili Lu
This study develops a releasable IL-15 superagonist that enhances antitumor immunity in cold tumors by activating CD25+CD8+ T cells while reducing toxicity.
bioRxiv · Aug 14, 2025 · PreprintImmunology