NF-κB dependent gene expression and plasma IL-1β, TNFα and GCSF drive transcriptomic diversity and CD4:CD8 ratio in people with HIV on ART.
Yingfan Wang, Germán G. Gornalusse, David A. Siegel, Alton S. Barbehenn, Rebecca Hoh, Jeffrey N. Martin, Frederick M. Hecht, Christopher D. Pilcher, Lesia Semenova, David M. Murdoch, David M. Margolis, Claire Levy, Keith R. Jerome, Cynthia D Rudin, Florian Hladik, , Edward P. Browne
This study identifies transcriptomic clusters in HIV patients on ART linked to immune recovery and inflammation markers, revealing novel subgroups with distinct immunological profiles.
bioRxiv · Feb 14, 2025 · PreprintMicrobiology