David A. Siegel

This study identifies transcriptomic clusters in HIV patients on ART linked to immune recovery and inflammation markers, revealing novel subgroups with distinct immunological profiles.

This study identifies host gene expression patterns associated with HIV reservoir size in treated individuals, linking inflammation, innate immunity, and potassium/gap junction channels to viral persistence.

The paper uses a massively parallel reporter assay to analyze 3' UTR sequences and shows that ARE length and registration affect mRNA stability and gene expression.

The paper investigates host genetic variations in MX1, CCR5Δ32, and MHC class I alleles in HIV+ non-controllers on ART and finds associations with HIV reservoir size.

The paper evaluates whether donor-multiplexed scRNA-seq introduces alloreactive gene expression changes and finds no detectable alloreactivity across three workflows.

MPRAudit quantifies the fraction of variance explained by unknown features in MPRA data, revealing sequence variation as the main driver of outcome variability but with known categories explaining only part of the variance.