Florian Hladik

Menstruation is associated with cyclical granulysin peaks in vaginal secretions despite stable expression by cervicovaginal immune cells

The paper shows granulysin levels in vaginal secretions peak during menstruation but not the luteal phase, linked to increased granulysin-expressing cells in the endocervical canal.

Computational Microbiome Pharmacology Analysis Elucidates the Anti-Cancer Potential of Vaginal Microbes and Metabolites

The paper develops a systems biology framework called the Pharmacobiome to analyze the anti-cancer potential of vaginal microbes and metabolites by comparing their effects on host gene expression to known drugs.

Identifying a Vaginal Microbiome-Derived Selective Antibiotic Metabolite via Microbiome Pharmacology Analysis

This study identifies a vaginal microbiome-derived antibiotic metabolite, Hydroxyisocaproate, using a systems biology approach to improve BV treatment.

Mucosal tissue NK cells directly mediate tissue protections and repair during infection

This study identifies a reparative role for mucosal NK cells in tissue protection and repair during infection, revealing their dual function in immunity and tissue homeostasis.

NF-κB dependent gene expression and plasma IL-1β, TNFα and GCSF drive transcriptomic diversity and CD4:CD8 ratio in people with HIV on ART.

This study identifies transcriptomic clusters in HIV patients on ART linked to immune recovery and inflammation markers, revealing novel subgroups with distinct immunological profiles.

Differences in expression of tumor suppressor, innate immune, inflammasome, and potassium/gap junction channel host genes significantly predict viral reservoir size during treated HIV infection

This study identifies host gene expression patterns associated with HIV reservoir size in treated individuals, linking inflammation, innate immunity, and potassium/gap junction channels to viral persistence.

Host Variation in Type I Interferon Signaling Genes (MX1), CCR5{triangleup}32, and MHC Class I Alleles in Treated HIV+ Non-Controllers Predict Viral Reservoir Size

The paper investigates host genetic variations in MX1, CCR5Δ32, and MHC class I alleles in HIV+ non-controllers on ART and finds associations with HIV reservoir size.

Cryopreservation of human mucosal leukocytes

This study identifies effective cryopreservation media and protocols for mucosal leukocytes, achieving over 75% recovery and providing a detailed protocol for their preservation.

Mucosal effects of tenofovir 1% gel

This study evaluates the mucosal effects of tenofovir 1% gel, finding broad biological impacts on rectal and vaginal tissues, including anti-inflammatory suppression and mitochondrial dysfunction.