Jeffrey N. Martin

Robust T and B cell activation is associated with rapid clearance of infectious SARS-CoV-2

The paper identifies immune cell activation patterns associated with rapid clearance of infectious SARS-CoV-2 in both unvaccinated and vaccinated individuals.

Persistently activated virus-specific CD8 T cells indicate antigen-driven immune aberrations in long COVID

The paper identifies persistently activated virus-specific CD8 T cells in long COVID patients, suggesting chronic antigen stimulation by SARS-CoV-2 or herpesvirus.

Plasma Proteomic Profiling Identifies a Subset of HIV Elite Controllers with Inflammatory Profiles Resembling People Without HIV

The paper identifies a subset of HIV elite controllers with proteomic profiles similar to uninfected individuals, associated with lower viral reservoirs and protective HLA alleles.

Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID

This study uses multiomic and spatial profiling of colorectal tissue and blood to show that Long COVID is linked to immune dysregulation and viral persistence, with stronger signals in tissue than blood.

Increased mannosylation of extracellular vesicles in Long COVID plasma provides a potential therapeutic target for Galanthus nivalis agglutinin (GNA) affinity resin

The paper identifies increased mannosylation of extracellular vesicles in Long COVID plasma and shows GNA affinity resin can remove them, potentially rebalancing immune and tissue-repair networks.

The effect of circulating neutralizing antibodies on the replication of SARS-CoV-2 variants following post-vaccination infections.

This study examines how pre-existing neutralizing antibodies affect viral shedding in post-vaccination SARS-CoV-2 infections, finding that higher titers reduce viral load and duration but are less effective against Omicron variants.

NF-κB dependent gene expression and plasma IL-1β, TNFα and GCSF drive transcriptomic diversity and CD4:CD8 ratio in people with HIV on ART.

This study identifies transcriptomic clusters in HIV patients on ART linked to immune recovery and inflammation markers, revealing novel subgroups with distinct immunological profiles.

Differences in expression of tumor suppressor, innate immune, inflammasome, and potassium/gap junction channel host genes significantly predict viral reservoir size during treated HIV infection

This study identifies host gene expression patterns associated with HIV reservoir size in treated individuals, linking inflammation, innate immunity, and potassium/gap junction channels to viral persistence.

Host Variation in Type I Interferon Signaling Genes (MX1), CCR5{triangleup}32, and MHC Class I Alleles in Treated HIV+ Non-Controllers Predict Viral Reservoir Size

The paper investigates host genetic variations in MX1, CCR5Δ32, and MHC class I alleles in HIV+ non-controllers on ART and finds associations with HIV reservoir size.