Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse
Yinan Zhao, Dandan Bai, You Wu, Dan Zhang, Mengying Liu, Yingpu Tian, Jinhua Lu, Haibin Wang, Shaorong Gao, Zhongxian Lu
This study shows that maternal Ezh1/2 deficiency disrupts H3K27 methylation in oocytes, leading to delayed restoration and impaired epiblast development, causing embryonic sub-lethality in mice.
Development · Jul 7, 2022Peer-reviewedDevelopmental Biology