Shaorong Gao

TEDDY reconstructs and characterizes TE-dependent isoforms across biological contexts, revealing regulatory networks and identifying novel regulators like Arid3a with clinical relevance in cancer.

This study investigates R-loop dynamics during mouse early embryonic development and shows their role in regulating transcription during the maternal-to-zygotic transition.

This study generates gene-modified cattle and sheep using haploid stem cells with a modified iCHI approach that enhances embryo development.

This study develops bidirectional pluripotent stem cells (BPSCs) capable of generating both trophoblast and epiblast lineages, enabling the recapitulation of post-gastrula development in vitro and in vivo.

The paper introduces cFOOT-seq, a method for high-resolution, quantitative detection of TF occupancy across the genome, and demonstrates its application in analyzing TF dynamics and dependencies.

This study shows KH0 and KH1 domains of FMR1 work together in m6A binding and phase separation, linking these processes to Fragile X Syndrome pathology.

The paper investigates CTCF chromatin occupancy during mouse pre-implantation development and identifies ADNP's role in modulating SINE B2-derived CTCF-binding sites.

The paper investigates how maternal H3.3 contributes to paternal genome reprogramming and minor zygotic genome activation in mice.

This study identifies metabolic features in mouse pre-implantation embryos and shows that NAD+ synthesis is essential for development and regulates minor ZGA through H3K27ac erasure.

This study shows that maternal Ezh1/2 deficiency disrupts H3K27 methylation in oocytes, leading to delayed restoration and impaired epiblast development, causing embryonic sub-lethality in mice.

The paper studies nucleosome dynamics in mouse zygotes after fertilization, identifying factors involved in zygotic genome activation.

The study reveals that m6A RNA methylation stabilizes maternal RNAs in mouse oocytes and promotes the degradation of 2-cell specific RNAs during early embryonic development.