Haibin Wang

High-salt diet disturbs the physiological uterine endothelial junction remodeling during pregnancy

This study shows that a high-salt diet disrupts uterine endothelial junction remodeling during pregnancy, leading to hypertension and adverse outcomes in mice.

CASP3-GSDME-mediated trophoblast pyroptosis contributes to systemic inflammation

The paper identifies CASP3-GSDME-mediated trophoblast pyroptosis as a driver of systemic inflammation in early-onset preeclampsia and shows Vitamin D suppresses this process.

Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse

This study shows that maternal Ezh1/2 deficiency disrupts H3K27 methylation in oocytes, leading to delayed restoration and impaired epiblast development, causing embryonic sub-lethality in mice.

A sexual dimorphic role of the miR-465 cluster in placental development

This study shows that miR-465 cluster ablation causes female conceptus degeneration and a male-biased sex ratio in mice, indicating a sexual dimorphism in placental development.