Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cells.
Amalie C. M. Couch, Shiden Solomon, Alessia Marrocu, Rodrigo R. R. Duarte, Yiqing Sun, Laura Sichlinger, Rugilė Matulevičiūtė, Lucia Dutan Polit, Bjørn Hanger, Shahram Y. Kordasti, Deepak P. Srivastava, Anthony Christopher Vernon
The paper shows that acute IL-6 exposure activates canonical IL-6R signaling in hiPSC-derived microglia but not neural progenitor cells, with implications for neurodevelopmental disorders.
bioRxiv · Aug 5, 2022 · PreprintNeuroscience