ImmCellTyper is a computational pipeline for analyzing CyTOF data, offering semi-supervised clustering and visualization tools to improve immune cell profiling accuracy and efficiency.

bioRxiv · Jan 15, 2024 · PreprintBioinformatics

Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cells.

Amalie C. M. Couch, Shiden Solomon, Alessia Marrocu, Rodrigo R. R. Duarte, Yiqing Sun, Laura Sichlinger, Rugilė Matulevičiūtė, Lucia Dutan Polit, Bjørn Hanger, Shahram Y. Kordasti, Deepak P. Srivastava, Anthony Christopher Vernon

The paper shows that acute IL-6 exposure activates canonical IL-6R signaling in hiPSC-derived microglia but not neural progenitor cells, with implications for neurodevelopmental disorders.

bioRxiv · Aug 5, 2022 · PreprintNeuroscience

ImmunoCluster: A computational framework for the non-specialist to profile cellular heterogeneity in cytometry datasets

James W. Opzoomer, Jessica Ann Timms, Kevin Blighe, Thanos P. Mourikis, Nicolas Chapuis, Richard Bekoe, Sedigeh Kareemaghay, Paola Nocerino, Benedetta Apollonio, Alan G. Ramsay, Mahvash Tavassoli, Claire N. Harrison, Francesca D. Ciccarelli, Peter J. Parker, Michaëla Fontenay, , Shahram Y. Kordasti

ImmunoCluster provides an R package for analyzing high-dimensional cytometry data, enabling non-specialists to profile cellular heterogeneity through scalable analysis and visualization tools.

eLife · Apr 30, 2021Peer-reviewedSystems Biology