Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcoholic liver disease
Yilin Yang, Panjamaporn Sangwung, Reiichiro Kondo, Yirang Jung, Matthew J. McConnell, Jain Jeong, Teruo Utsumi, William C. Sessa, Yasuko Iwakiri
This study shows that alcohol-induced Hsp90 acetylation in liver sinusoidal endothelial cells (LSECs) reduces eNOS interaction and NO production, contributing to alcoholic liver disease, and suggests HDAC6 overexpression as a therapeutic approach.
Journal of Hepatology · Mar 5, 2021Peer-reviewedMolecular Biology