William C. Sessa

This study identifies macropinocytosis as the mechanism by which PAI1 is internalized by endothelial cells, allowing it to evade degradation and inhibit eNOS.

This study identifies two yeast enzymes, Env9 and Tda5, that perform distinct steps in dolichol biosynthesis, replacing the dual role of DHRSX in humans.

This study shows that loss of NgBR/cis-PTase function in the liver leads to fatty liver disease that progresses to hepatocellular carcinoma with 100% penetrance, and DGAT2 inhibition prevents this progression.

This study shows that alcohol-induced Hsp90 acetylation in liver sinusoidal endothelial cells (LSECs) reduces eNOS interaction and NO production, contributing to alcoholic liver disease, and suggests HDAC6 overexpression as a therapeutic approach.

The paper shows that N-glycan modifications regulate endothelial-to-hematopoietic transition by affecting glycosylation enzymes and HSPC production.

This study identifies Akt's role in dorsal aorta formation by showing it sustains arterial progenitor specification and segregation in zebrafish.