Author

Teruo Utsumi

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:rat· 4 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Matthew J. McConnelliD· 4 shared Yasuko IwakiriiD· 4 shared Jain Jeong· 3 shared Yilin YangiD· 3 shared Hui‐Chun HuangiD· 2 shared Shao‐Jung HsuiD· 2 shared Xuchen ZhangiD· 2 shared Chao Dong· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersPathology

Matthew J. McConnellORCID

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4 papers

Recent·Most cited

Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing Macrophages

Ruixue Ma, Li Gong, Chao Dong, Teruo Utsumi, Jiewen Qi, Zhen W. Zhuang, Xuchen Zhang, Yilin Yang, Matthew J. McConnell, Hui‐Chun Huang, Yasuko Iwakiri

This study shows that increased VCAM-1 in hepatic artery endothelial cells and portal fibroblasts recruits Spp1+ macrophages, driving fibrosis in portal hypertension.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2026Peer-reviewedPathology

Liver Lymphatic Dysfunction as a Driver of Fibrosis and Cirrhosis Progression

Jain Jeong, Shao‐Jung Hsu, Daiki Horikami, Teruo Utsumi, Yilin Yang, Nikolai Arefyev, Xuchen Zhang, Shi‐Ying Cai, James L. Boyer, Rolando Garcia-Milan, Masatake Tanaka, Matthew J. McConnell, Hui‐Chun Huang, Yasuko Iwakiri

This study shows that impaired liver lymphatic function drives fibrosis and cirrhosis progression and identifies VEGF-C as a potential therapeutic target.

bioRxiv · Jan 11, 2025 · PreprintPathology

Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcoholic liver disease

Yilin Yang, Panjamaporn Sangwung, Reiichiro Kondo, Yirang Jung, Matthew J. McConnell, Jain Jeong, Teruo Utsumi, William C. Sessa, Yasuko Iwakiri

This study shows that alcohol-induced Hsp90 acetylation in liver sinusoidal endothelial cells (LSECs) reduces eNOS interaction and NO production, contributing to alcoholic liver disease, and suggests HDAC6 overexpression as a therapeutic approach.

Journal of Hepatology · Mar 5, 2021Peer-reviewedMolecular Biology

Enhanced meningeal lymphatic drainage ameliorates neuroinflammation and hepatic encephalopathy in cirrhotic rats

Shao‐Jung Hsu, Chihao Zhang, Jain Jeong, Seong-il Lee, Matthew J. McConnell, Teruo Utsumi, Yasuko Iwakiri

This study shows that enhancing meningeal lymphatic drainage reduces neuroinflammation and improves motor function in cirrhotic rats with hepatic encephalopathy.

Gastroenterology · Nov 20, 2020Peer-reviewedNeuroscience