FCRL5 is a fucose-sensitive IgG-Fc receptor with binding properties distinct from classical Fcγ receptors
Nick van der Hoeven, Miles D. Holborough-Kerkvliet, Yixiang Bao, Arthur E. H. Bentlage, Pleuni Ooijevaar‐de Heer, Ninotska I. L. Derksen, Timon Damelang, Bart-Jan de Kreuk, Aran F. Labrijn, Gestur Vidarsson, Theo Rispens
This study characterizes FCRL5 as a low-affinity IgG-Fc receptor with distinct binding properties, showing preference for afucosylated IgG and identifying key residues for interaction.
bioRxiv · Jul 7, 2026 · PreprintImmunology