Gestur Vidarsson

This paper develops an enzymatic platform to synthesize diverse mAb glycoforms and uses them to study α-Gal immunogenicity and FcγR binding.

The paper identifies BTK as a therapeutic target in antibody-mediated autoimmune diseases by mapping FcγR signaling in neutrophils using kinase inhibitors and disease models.

The paper identifies pregnancy-specific and fetal-specific plasma proteomic and N-glycoproteomic signatures by comparing maternal, cord blood, and non-pregnant control samples.

The paper characterizes two anti-HPA-1a antibodies from a severe FNAIT case, showing functional differences in platelet activation through FcγRIIa engagement.

This study presents the high-resolution cryo-EM structure of integrin αIIbβ3 bound to an anti-HPA-1a antibody, revealing how it blocks integrin activation and platelet aggregation.

This paper develops sensitive ELISAs to quantify J-chain-containing IgA and IgM, revealing that 10% of circulating IgA is polymeric and enabling high-throughput analysis of polymeric IgA responses.

This study characterizes FCRL5 as a low-affinity IgG-Fc receptor with distinct binding properties, showing preference for afucosylated IgG and identifying key residues for interaction.

The paper identifies structurally promiscuous IgA1 clones in human serum that exist as both monomers and J-chain-coupled dimers, challenging the view that these forms are clonally distinct.

This study transfers IgG from Long COVID patients to mice, inducing distinct symptoms based on patient subgroups, supporting a causative role for IgGs in Long COVID.

This study shows ERK5 inhibition reduces neutrophil ROS release and ameliorates EBA, suggesting ERK5 as a therapeutic target in ROS-driven autoimmune diseases.

This study shows that IgG hexamerization is critical for triggering acute lung injury and suggests therapeutic strategies targeting hexamer formation.

The paper identifies CD5L as a component of circulatory IgM, showing it forms a complex with J-chain-containing pentamers and affects IgM receptor binding.