Theo Rispens

This paper develops sensitive ELISAs to quantify J-chain-containing IgA and IgM, revealing that 10% of circulating IgA is polymeric and enabling high-throughput analysis of polymeric IgA responses.

This study characterizes FCRL5 as a low-affinity IgG-Fc receptor with distinct binding properties, showing preference for afucosylated IgG and identifying key residues for interaction.

The paper characterizes early antigen-specific B cell responses after vaccination, identifying distinct clusters with different contraction dynamics and potential roles in memory B cell formation.

The paper analyzes transcriptome and proteome data of human naive and memory B cells to identify isotype-specific phenotypes, finding distinct expression profiles in IgG4-switched B cells.

The paper identifies novel stages in IgG memory B cell and antibody-secreting cell differentiation by analyzing antigen-specific B cells from different pathogens using high-dimensional flow cytometry.

The paper identifies CD5L as a component of circulatory IgM, showing it forms a complex with J-chain-containing pentamers and affects IgM receptor binding.