Ninotska I. L. Derksen

Assessment of polymeric immunoglobulin A and M via detection of the joining chain

This paper develops sensitive ELISAs to quantify J-chain-containing IgA and IgM, revealing that 10% of circulating IgA is polymeric and enabling high-throughput analysis of polymeric IgA responses.

FCRL5 is a fucose-sensitive IgG-Fc receptor with binding properties distinct from classical Fcγ receptors

This study characterizes FCRL5 as a low-affinity IgG-Fc receptor with distinct binding properties, showing preference for afucosylated IgG and identifying key residues for interaction.

Transcriptome-Proteome analysis of human naive and memory B cell subsets reveal isotype and subclass-specific phenotypes

The paper analyzes transcriptome and proteome data of human naive and memory B cells to identify isotype-specific phenotypes, finding distinct expression profiles in IgG4-switched B cells.

CD5L is a canonical component of circulatory IgM

The paper identifies CD5L as a component of circulatory IgM, showing it forms a complex with J-chain-containing pentamers and affects IgM receptor binding.