Author

Yiyi Cheng

University of GlasgowPrimary ORCID profile (0009-0002-5151-3212 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Yiyi ChengiD1 paper · Guangzhou Laboratory

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew McCluskeyiD· 1 shared Domenico SommaiD· 1 shared Olympia M HardyiD· 1 shared Ross F LaidlawiD· 1 shared Thomas D. OttoiD· 1 shared Toby KettlewelliD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBioinformatics

Andrew McCluskeyORCID

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1 paper

Recent·Most cited

Cell DiffErential Expression by Pooling (CellDEEP) highlights issues in differential gene expression in scRNA-seq

Yiyi Cheng, Toby Kettlewell, Ross F Laidlaw, Olympia M Hardy, Andrew McCluskey, Thomas D. Otto, Domenico Somma

CellDEEP improves differential gene expression analysis in scRNA-seq by aggregating cells into metacells, reducing false positives and increasing true positives compared to single-cell and pseudobulk methods.

bioRxiv · Mar 11, 2026 · PreprintBioinformatics