Domenico Somma

CellDEEP improves differential gene expression analysis in scRNA-seq by aggregating cells into metacells, reducing false positives and increasing true positives compared to single-cell and pseudobulk methods.

This study identifies PIEZO1 as a mechanosensor driving inflammation-permissive macrophage phenotypes in synovial tissue, contributing to joint inflammation in RA.

This study shows human synovial tissue-resident macrophages develop from monocytes guided by fibroblast-derived cues in specific spatial niches, using a novel organoid system.

paraCell provides an interactive tool for analyzing and visualizing host-parasite single-cell RNA-Seq data without requiring programming skills.

This study shows that PROS1 released by lung basal cells during SARS-CoV-2 infection reduces inflammation, promotes epithelial repair, and enhances antigen presentation.

This study identifies distinct myeloid DC subsets in synovial tissue across health and RA states, showing their roles in inflammation and tolerance.