Author

Toby Kettlewell

University of GlasgowORCID 0009-0001-1225-3318Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:deconvolution· 1 Organism:human· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Andrew McCluskeyiD· 2 shared Thomas D. OttoiD· 2 shared Adrian M SmithiD· 1 shared David Andrew GunniD· 1 shared Domenico SommaiD· 1 shared Olympia M HardyiD· 1 shared Rhiannon KunduiD· 1 shared Ross F LaidlawiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersBioinformatics

Andrew McCluskeyORCID

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2 papers

Recent·Most cited

BioinformaticsBMC MethodsPeer-reviewedJul 8, 2026

BLASE: Bulk Linkage Analysis for Single Cell Experiments - Teasing Out the Secrets of Bulk Transcriptomics with Trajectory Analysis

Andrew McCluskey, Toby Kettlewell, Adrian M Smith…·Thomas D. Otto

BLASE uses scRNA-seq references to analyze bulk RNA-seq data, identifying trajectory progress and correcting developmental differences in differential expression analysis.

DOI 10.1186/s44330-026-00082-7

bulk RNA-seqscRNA-seq

𝕏 PostBluesky

BioinformaticsbioRxivPreprintMar 11, 2026

Cell DiffErential Expression by Pooling (CellDEEP) highlights issues in differential gene expression in scRNA-seq

Yiyi Cheng, Toby Kettlewell, Ross F Laidlaw…·Domenico Somma

CellDEEP improves differential gene expression analysis in scRNA-seq by aggregating cells into metacells, reducing false positives and increasing true positives compared to single-cell and pseudobulk methods.

DOI 10.64898/2026.03.09.710522

humanscRNA-seq

𝕏 PostBluesky