Oral antigen exposure under co-stimulation blockade generates Treg cells to establish immune tolerance despite prior sensitization
Masaya Arai, Ryoji Kawakami, Yamami Nakamura, Yoko Naito, Daisuke Motooka, Atsushi Sugimoto, Tomiko Kimoto, Naganari Ohkura, Norihisa Mikami, Shimon Sakaguchi
This study shows that oral antigen exposure with co-stimulation blockade generates stable regulatory T cells in antigen-sensitized mice, establishing long-term immune tolerance.
bioRxiv · Apr 2, 2025 · PreprintImmunology