Prolactin links psychological stress to psoriasis via a fibroblast-chemokine pathway
Huiyao Ge, Shiyao Zhou, Yu Zhao, Xinwen Zhang, Mei Chen, Pan Gao, Shengxiu Liu, Qitian Mu, Difeng Fang, Xin Hou, Yong Liang
This study identifies prolactin as a mediator linking psychological stress to psoriasis through a fibroblast-chemokine pathway, showing that targeting PRL signaling reduces disease severity in mice.
bioRxiv · Oct 11, 2025 · PreprintImmunology