Sparse, random sampling is sufficient for central tolerance
Hannah V. Meyer, Sanjoy Dasgupta, Amitava Banerjee, Yong Lin, Rishvanth K. Prabakar, Sarah R. Chapin, Carl Kingsford, Saket Navlakha
The paper shows that sparse, random sampling of self peptides in the thymus is sufficient for T cell tolerance to most peripheral self peptides, supported by experimental data and machine learning analysis.
bioRxiv · Dec 12, 2025 · PreprintImmunology