Hirofumi Noguchi

Adolescent Seizure Impacts Oligodendrocyte Development, Neuronal-Glial Circuit Formation, and Myelination

This study shows that adolescent seizures increase oligodendrocyte progenitor proliferation, reduce mature oligodendrocyte numbers, and impair myelination and neuron-OPC connectivity.

Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging

This study shows that Shh from mossy cells supports NSC pool maintenance after seizures and in aging by promoting neurogenesis and NSC self-renewal.

Neuronal Activity Alters Neuron to OPC Synapses

This study shows that neuronal activity influences OPC activation, synapse formation onto OPCs, and the balance of excitatory and inhibitory synapses.

NMDA receptors control cortical axonal projections via EPHRIN-B/EPHB signaling

This study shows that NMDA receptors, specifically NR2B-containing ones, control callosal axonal projections in the primary somatosensory cortex through interactions with EPHRIN-B/EPHB, independent of ion channel function.

Suppressor of Fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

This study shows that Sufu regulates Shh signaling to control the expansion and quiescence of neural stem cells in the developing dentate gyrus.

Suppressor of Fused controls the proliferation of postnatal neural stem and precursor cells via a Gli3-dependent mechanism

This study shows that Sufu deletion in neural progenitors causes increased proliferation and reduced survival of stem/precursor cells in the dorsal V-SVZ via a Gli3-dependent mechanism.