A K27-linked Ubiquitin Checkpoint Controls NOTCH Homeostasis
Behzad Mansoori, Ying Song, Tian Zhang, Zihan Zheng, Qing Zhu, Shun Li, Mckenna Reale, Christian Pangilinan, Janvhi Suresh Machhar, Jinghui Liang, Jason Chang, Young-Kwon Hong, Gerald B. Wertheim, Maureen E. Murphy, Yong-Mi Kim, , Chengyu Liang
This study identifies UVRAG as a negative regulator of NOTCH1 by promoting K27-linked ubiquitination and lysosomal degradation, revealing a checkpoint to prevent excessive NOTCH signaling.
bioRxiv · Dec 19, 2025 · PreprintMolecular Biology