Maureen E. Murphy

A phylogeny-guided framework for decoding mechanisms of human endogenous retrovirus regulation in health and disease

ERVmancer is a phylogeny-informed method that resolves read-mapping ambiguity for HERVs, outperforming existing approaches and revealing new biology in breast cancer.

Variation at the R181 residue of p53 confers loss of p53 DNA binding cooperativity with the retention of mitochondrial-associated apoptosis

This study shows that p53 variants with R181 mutations retain mitochondrial apoptosis function but lose DNA binding cooperativity, leading to reduced cancer risk.

A K27-linked Ubiquitin Checkpoint Controls NOTCH Homeostasis

This study identifies UVRAG as a negative regulator of NOTCH1 by promoting K27-linked ubiquitination and lysosomal degradation, revealing a checkpoint to prevent excessive NOTCH signaling.

NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors

This study identifies NAB2-STAT6 as a driver of a neuroendocrine program in SFTs through its role in enhancing EGR1 target gene expression.

LANA-Dependent Transcription-Replication Conflicts and R-Loops at the Terminal Repeats (TR) Correlate with KSHV Episome Maintenance

The paper shows LANA binding at KSHV TRs causes R-loops and histone modifications linked to episome maintenance.

Regulation of alternative polyadenylation isoforms of Timp2 is an effector event of RAS signaling in cell transformation

This study shows that RAS signaling regulates Timp2 alternative polyadenylation isoforms, with the long 3UTR isoform enhancing secreted protein expression and contributing to cell transformation.

p53 suppresses mutagenic RAD52 and POLθ pathways by orchestrating DNA replication restart homeostasis

This study identifies p53's role in suppressing mutagenic DNA repair pathways by regulating replication restart, revealing its importance in genomic stability and cancer therapy resistance.