Pemphigus vulgaris autoantibodies induce an ER stress response
Coryn L Hoffman, Navaneetha Krishnan Bharathan, Yoshitaka Shibata, W. Giang, Johann Eli Gudjonsson, John T. Seykora, Stephen Marsh Prouty, Sara N. Stahley, Aimee S. Payne, Andrew P. Kowalczyk
This study shows that PV autoantibodies trigger ER stress, leading to desmosome disruption and cell adhesion loss, and suggests ER stress as a therapeutic target.
Journal of Investigative Dermatology · Feb 3, 2025Peer-reviewedCell Biology