A Brugada-related KCNT1 mutation unveils its conductance-independent activation of store-operated Ca 2+ entry
Pei-Ju Tsai, Yu-Chiao Lin, Hsuan-Chao Lin, You-Yi Li, Jyh‐Ming Jimmy Juang, Chien‐Yuan Pan, Wen‐Pin Chen, Hsi‐Chun Chao, Feng‐Chiao Tsai
This paper investigates the role of KCNT1 mutations in Ca2+ homeostasis and cardiomyocyte function, showing that its cytoplasmic tail modulates ER-PM contacts and Ca2+ dynamics independently of its ion-conducting function.
bioRxiv · Jun 12, 2026 · PreprintMolecular Biology