Molecular BiologybioRxivPreprint
A Brugada-related KCNT1 mutation unveils its conductance-independent activation of store-operated Ca 2+ entry
Pei-Ju Tsai, Yu-Chiao Lin, Hsuan-Chao Lin…·Feng‐Chiao Tsai
This paper investigates the role of KCNT1 mutations in Ca2+ homeostasis and cardiomyocyte function, showing that its cytoplasmic tail modulates ER-PM contacts and Ca2+ dynamics independently of its ion-conducting function.
DOI 10.64898/2026.06.12.731813