RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma
Elizabeth A. Mendes, Aanandi Munshi, Archana Singh, Maisie D. Evans, Hsien-Chao Chou, Yong Yean Kim, Young Song, Ara Jo, Daniel Lee, Jaida Ciampi, Audrey L. Chambers, Samantha Weitzel, Michael D. Deel, Rex C. Bentley, Javed Khan, , Corinne Mary Linardic
This study identifies RUNX2 as a druggable target in fusion-positive rhabdomyosarcoma, showing its inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and reduces tumor growth.
bioRxiv · Jul 21, 2025 · PreprintCancer Biology