ISKNV-pORF71 hijacks outer mitochondrial membrane-localized VDAC2 to the nucleus, enhancing apoptosis by disrupting mitochondrial membrane permeability
Hetong Zhang, Yuting Fu, Youyong Dong, Hemei Qi, Shaoping Weng, Jianguo He, Chuanfu Dong
This study shows that ISKNV-pORF71 hijacks VDAC2 from mitochondria to the nucleus, disrupting mitochondrial membrane permeability and enhancing apoptosis during infection.
bioRxiv · Nov 13, 2025 · PreprintMicrobiology