Modeling Thoracic Aortic Dissection Using Patient-Specific iPSCs Reveals VSMC Dysfunction and Extracellular Matrix Dysregulation
Peifeng Jin, Yubin Xu, Sixian Wang, Lu Ding, Yuhao Chen, Miqi Zhou, Xiufang Chen, Xiaofang Fan, Yongsheng Gong, Ming Li, Yongyu Wang
This study uses patient-specific iPSCs to model thoracic aortic dissection, revealing VSMC dysfunction and extracellular matrix dysregulation linked to COL4A2 mutations and TGF-β signaling.
Stem Cells International · Jan 1, 2025Peer-reviewedPathology