Author

Xiufang Chen

Wenzhou Medical UniversityORCID 0000-0002-8795-6923Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Lu DingiD· 2 shared Peifeng JiniD· 2 shared Yongyu WangiD· 2 shared Congkuo DuiD· 1 shared Jianshe MaiD· 1 shared Jinbiao Lai· 1 shared Jiwen Yang· 1 shared Lei Zhang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPathology

Lu DingORCID

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2 papers

Recent·Most cited

VGLL4 promotes thoracic aortic aneurysm and dissection by disrupting extracellular matrix homeostasis via WISP1-mediated TIMP3/MMP9 imbalance

Lu Ding, Jianshe Ma, Pinmeng Diao, Runze Dong, Yutao Tong, Jinbiao Lai, Yuyue Shao, Minjie Hu, Jiwen Yang, Peifeng Jin, Xiaofang Fan, Yongsheng Gong, Congkuo Du, Xuejiao Chen, Xiufang Chen, , Yongyu Wang

This study identifies VGLL4 as a mechanosensitive regulator of TAAD by disrupting ECM homeostasis through the WISP1-TIMP3/MMP9 axis.

bioRxiv · Aug 30, 2026 · PreprintPathology

Modeling Thoracic Aortic Dissection Using Patient-Specific iPSCs Reveals VSMC Dysfunction and Extracellular Matrix Dysregulation

Peifeng Jin, Yubin Xu, Sixian Wang, Lu Ding, Yuhao Chen, Miqi Zhou, Xiufang Chen, Xiaofang Fan, Yongsheng Gong, Ming Li, Yongyu Wang

This study uses patient-specific iPSCs to model thoracic aortic dissection, revealing VSMC dysfunction and extracellular matrix dysregulation linked to COL4A2 mutations and TGF-β signaling.

Stem Cells International · Jan 1, 2025Peer-reviewedPathology