ORC binding to Heterochromatin Protein 1 through intrinsically disordered regions is required for heterochromatin structure and function
Yuchang Luo, Srivarsha Rajshekar, Harish Kumar, James M. Berger, Gary H. Karpen, Michael R. Botchan
This study shows that ORC interacts with HP1a via specific motifs to regulate heterochromatin structure and function in Drosophila.
bioRxiv · Jul 20, 2026 · PreprintBiochemistry