Dynamic changes in tRNA modifications and abundance during T-cell activation
Roni Rak, Michal Polonsky, Inbal Eizenberg-Magar, Yufeng Mo, Yuriko Sakaguchi, Orel Mizrahi, Aharon Nachshon, Shlomit Reich-Zeliger, Noam Stern‐Ginossar, Orna Dahan, Tsutomu Suzuki, Nir Friedman, Yitzhak Pilpel
The paper examines dynamic changes in tRNA modifications and abundance during T-cell activation, finding reduced wybutosine and ms2t6A modifications that may increase ribosomal frameshifting and facilitate HIV infection.
Proceedings of the National Academy of Sciences · Oct 12, 2021Peer-reviewedGenomics