Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice
Eisuke Okugawa, Himari Ogino, Tomofumi Shigenobu, Yuko Yamakage, Hitomi Tsuiji, Hisashi Oishi, Takao Kohno, Mitsuharu Hattori
This study shows that inhibiting Reelin cleavage enhances its signaling, leading to hippocampal layer disturbances and increased dendritic branching, suggesting Reelin cleavage is critical for normal brain development.
Scientific Reports · Mar 11, 2020Peer-reviewedNeuroscience