Mitsuharu Hattori

This study identifies Twinfilin-1 phosphorylation as a key component of reelin signaling that regulates actin dynamics and spine development in neurons.

This study identifies RSS as a recyclinopathy caused by dysfunction in the Commander endosomal recycling pathway, linking it to multiple tissue malformations.

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

This study identifies ADAMTS2 as a key regulator of radial neuronal migration by activating TGF-β signaling through ECM remodeling at the subplate layer during neuronal development.

This study shows that dipeptide repeat proteins from C9ORF72 mutations disrupt GEM body formation and cause SMN protein mislocalization in motor neurons.

This study shows that inhibiting Reelin cleavage enhances its signaling, leading to hippocampal layer disturbances and increased dendritic branching, suggesting Reelin cleavage is critical for normal brain development.