Author

Hitomi Tsuiji

Nagoya City UniversityORCID 0000-0003-2234-726XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Mitsuharu HattoriiD· 2 shared Antonios ApostolopoulosiD· 1 shared Eisuke Okugawa· 1 shared Haruhisa InoueiD· 1 shared Hideyuki OkanoiD· 1 shared Himari Ogino· 1 shared Hisashi OishiiD· 1 shared Ikuma Nakagawa· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Mitsuharu HattoriORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMay 14, 2023

CRISPRδ: dCas13-mediated translational repression for accurate gene silencing in mammalian cells

Antonios Apostolopoulos, Hitomi Tsuiji, Yuichi Shichino, Shintaro Iwasaki

CRISPRδ uses dCas13 to specifically block translation without affecting mRNA stability, achieving high gene knockdown specificity in mammalian cells.

2 citations

mouseCRISPR screen

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NeurosciencebioRxivPreprintMar 24, 2021

C9ORF72 dipeptide repeat proteins disrupt formation of GEM bodies and induce aberrant accumulation of survival of motor neuron protein

Yuma Kato, Minnie Yokogawa, Ikuma Nakagawa…·Hitomi Tsuiji

This study shows that dipeptide repeat proteins from C9ORF72 mutations disrupt GEM body formation and cause SMN protein mislocalization in motor neurons.

3 citations

humanproteomics

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NeuroscienceScientific ReportsPeer-reviewedMar 11, 2020

Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice

Eisuke Okugawa, Himari Ogino, Tomofumi Shigenobu…·Mitsuharu Hattori

This study shows that inhibiting Reelin cleavage enhances its signaling, leading to hippocampal layer disturbances and increased dendritic branching, suggesting Reelin cleavage is critical for normal brain development.

29 citations

mouseprotein structure

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